The company tasked Publicis Hong Kong with developing the regional campaign, which features the brand's celebrity spokesperson Michele Reis.
According to Peter Oesch, senior account director at Publicis, the ad was filmed in Hong Kong in a bid to localise the brand's communication in the region.
"This product is unique in that it is a 'cream' whitening mask, while others in the market tend to be 'paper' masks,"he explained.
"Skin whitening products are not available in Europe, but are very popular in Asia, so it was more appropriate to develop the campaign here and the company wanted to 'Asianise' the communication."
L'Oreal's Dermo Expertise Whitening Mask, unlike paper whitening masks, uses a triple melanin block for intense whitening of the skin.
It also has an exfoliating feature, which can be activated by massaging the face just before the cream is rinsed off.
L'Oreal Hong Kong consumer product division general manager, Chris Neo, added: "The challenge in making this new TVC was threefold: firstly, to deliver that uniqueness.
"Secondly we want to communicate our brand equity that represents quality, technology and is distinctively French.
"Thirdly to create an execution driven by the dynamics and personality that is definitely modern-day Asian."
The 30-second commercial - which airs in Hong Kong this week - will also be rolled out in regional markets, including Singapore, Malaysia, Thailand, Taiwan and China, in July.
The ad will also be looped on TV screens at L'Oreal's new boutique in Hong Kong's shopping district Causeway Bay.
Added Oesch: "The TVC makes an analogy between maximising the skin whitening and increasing the brightness of the television screen.
"You see Michele Reis using a remote control to activate the brightness bar on the viewers' TV. As the bar goes up, you can see the screen getting brighter. The camera focuses on the product to show viewers this is a cream not paper mask."