The cosmetics and fragrance giant has been searching for an agency to push it beyond its traditional media activities, which have focused on luxury magazines and television to date.
Estée's huge account has been split by agencies and by market, with OMD handling the business in Australia and Japan, it's largest Asian market.
The Omnicom network saw off competition from a field believed to include MindShare, MPG and Starcom to take on the consolidated account worth US$75 million in Asia Pacific.
The focus will be on three "driver" markets: China, Korea and Japan. Estée's biggest brand in Asia is Clinique, but Aramis, Origins and the eponymous brand will also receive media support this year.
The news marks an extraordinary week for OMD which yesterday (Tuesday) was confirmed as Intel's global media agency of record.