The Nick Takes Over Your Room programme is the channel's most ambitious locally-produced show over the past 18 months.
It is one of several initiatives, which includes the exclusive broadcast rights of the Manchester United Premier Cup tournament in the US for juniors, aiming to build audience share in the region and to close the gap with current market leader Cartoon Network.
Presently, 17 million households have access to Nickelodeon, while the figure for Cartoon Network is about 30 million.
Nickelodeon marketing manager Lucy Young said: "The biggest objective is to make kids feel they are part of the channel and that means to engage them in a fun and interactive manner."
The show will go on air in September on the channel's Southeast Asia feed, and the chosen kids - aged seven to 14 - will be able to interview family and friends, introduce their favourite Nickelodeon shows, interact with viewers with games and puzzles and take part in a series of physical and mental challenges.
A marketing campaign has kicked off in Singapore, including the distribution of entry forms at Ikea outlets, as well as selected supermarkets and convenience stores where Qoo is sold.
Ikea marketing communications manager Angeline Tan said the company was participating in the show because it was "a great way to familiarise people with kids' furniture".
Tan described the programme as unique but in sync with Ikea's marketing strategy of letting their customers interact with their products.
The same is true for kids. "This is the first time we have targeted children in Singapore, and they will add depth to our future," she said.