The objective is to place a greater emphasis on the newsstand platform to complement its direct mail programmes - the monthly's preferred means of building and maintaining its circulation.
About 90 per cent of sales is generated via subscriptions, with the remainder coming from newsstands.
Reader's Digest Asia managing director Rosemarie Wallace said the figures showed that "there was an opportunity to place some effort on the retail channel".
The campaign, developed by Ogilvy & Mather unit Relationship Marketing Group, consists of eye-catching posters placed at bookstores and newsstands to target urban professionals and shoppers within the 20 to 40 age group.
More than 6,000 posters have been printed, covering the magazine's three main editions - English, Chinese and Thai - as well as the key markets of Hong Kong, Taiwan, Singapore, Malaysia and Thailand.
Wallace, said the retail poster campaign coincides with an initiative to revitalise the editorial product.
The changes, to be unveiled next month, includes adding new business and lifestyle sections, depending on the edition.
Wallace said: "We do have a fairly set format which has been around for a while.
"But with quarterly reader polls, we are making the revitalisation process something that should be done on an ongoing basis."