Among the changes are the inclusion of new segments such as 'Cool trends', 'Toys and Connections', 'Web finds', 'Headlines' and 'DIY'.
CNBC Asia-Pacific vice-president for programming, Cynthia Owens, said the change formally cements an evolution made in the past few years which had diverted viewers' attention from hi-tech stocks and IPOs to how technology could benefit them in their personal lives.
"We were already talking about the issues that will be raised in the new segments but the new segments along with a new set will underline the focus on keeping viewers on top of the latest trends," she said.
Technology specialist Keith Liu and correspondent Eunice Yoon will continue to host the weekly show, currently sponsored by Nokia.
Generation-e's core audience is business professionals who need to stay on top of hi-tech trends.
Owens added that while the viewership skew was biased towards younger executives, tailormade segments would also be produced for people in their 40s and 50s who were still learning to be comfortable technology.